MedCallyLooking up the FDA label…
Looking up the FDA label…
Macrolide Antimicrobial
Clarithromycin is a macrolide antimicrobial indicated for mild to moderate infections caused by designated, susceptible bacteria in the following: Acute Bacterial Exacerbation of Chronic Bronchitis in Adults Acute Maxillary Sinusitis Community-Acquired Pneumonia Pharyngitis/Tonsillitis Uncomplicated Skin and Skin Structure Infections Acute Otitis Media in Pediatric Patients Treatment and Prophylaxis of Disseminated Mycobacterial Infections Helicobacter pylori Infection and Duodenal Ulcer Disease in Adults Limitations of Use To reduce the development of drug-resistant bacteria and maintain the effectiveness of clarithromycin tablets and other antibacterial drugs, clarithromycin tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. 1.1 Acute Bacterial Exacerbation of Chronic Bronchitis Clarithromycin tablets are indicated in adults for the treatment of mild to moderate infections caused by susceptible isolates due to Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, or Streptococcus pneumoniae. …
Provide the following instructions or information about clarithromycin tablets to patients: Important Administration Instructions Advise patients that clarithromycin tablets can be taken with or without food and can be taken with milk. Drug Interactions Advise patients that clarithromycin may interact with some drugs; therefore, advise patients to report to their healthcare provider the use of any other medications. Diarrhea Advise patients that diarrhea is a common problem caused by antibacterials including clarithromycin which usually ends when the antibacterial is discontinued. Sometimes after starting treatment with antibacterials, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibacterial. If this occurs, instruct patients to contact their healthcare provider as soon as possible. Embryo-Fetal Toxicity Advise females of reproductive potential that that if pregnancy occurs while taking this drug, there is a potential hazard to the fetus. Antibacterial Resistance Counsel patients that antibacterial drugs including clarithromycin should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Clarithromycin is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may decrease the effectiveness of the immediate treatment and increase the likelihood that bacteria will develop resistance and will not be treatable by clarithromycin or other antibacterial drugs in the future. Potential for Dizziness, Vertigo and Confusion There are no data on the effect of clarithromycin on the ability to drive or use machines. …
The following serious adverse reactions are described below and elsewhere in the labeling: Acute Hypersensitivity Reactions QT Prolongation Hepatotoxicity Serious Adverse Reactions Due to Concomitant Use with Other Drugs Clostridium difficile Associated Diarrhea Exacerbation of Myasthenia Gravis Most frequent adverse reactions for both adult and pediatric populations in clinical trials: abdominal pain, diarrhea, nausea, vomiting, dysgeusia To report SUSPECTED ADVERSE REACTIONS, contact Sandoz Inc. at 1-800-525-8747…
Having one of these?
A doctor will tell you whether it matters and what to do about it. Written answer, a week of free follow-ups.
Ask a doctor — $19.99Hypersensitivity to clarithromycin or any macrolide drug Cisapride and pimozide History of cholestatic jaundice/hepatic dysfunction with use of clarithromycin Colchicine in renal or hepatic impairment Lomitapide, lovastatin, and simvastatin Ergot alkaloids (ergotamine or dihydroergotamine) Lurasidone 4.1 Hypersensitivity Clarithromycin tablets are contraindicated in patients with a known hypersensitivity to clarithromycin, erythromycin, or any of the macrolide antibacterial drugs. 4.2 Cisapride and Pimozide Concomi…
Adults: clarithromycin tablets 250 mg or 500 mg every 12 hours for 7 to 14 days H. pylori eradication (in combination with lansoprazole/amoxicillin, omeprazole/amoxicillin, or omeprazole): clarithromycin tablets 500 mg every 8 or 12 hours for 10 to 14 days. See full prescribing information (FPI) for additional information. Pediatric Patients: clarithromycin 15 mg/kg/day divided every 12 hours for 10 days Mycobacterial Infections: clarithromycin tablets 500 mg every 12 hours; clarithromycin tablets 7.5 mg/kg up to 5…
Co-administration of clarithromycin tablets is known to inhibit CYP3A, and a drug primarily metabolized by CYP3A may be associated with elevations in drug concentrations that could increase or prolong both therapeutic and adverse effects of the concomitant drug. Clarithromycin tablets should be used with caution in patients receiving treatment with other drugs known to be CYP3A enzyme substrates, especially if the CYP3A substrate has a narrow safety margin (e.g., carbamazepine) and/or the substrate is extensively m…
Taking something else alongside it?
Interaction warnings are written per drug, not for your particular combination. A doctor can check yours.
Ask about my combinationWorks in a similar way — macrolides
These are different medicines in the same family, not swaps for each other. Which one suits you is a prescribing decision.